Integrator termination complex
Nettet5. aug. 2024 · The Integrator complex inhibits transcription elongation at ∼15% of mRNA genes Integrator targets promoter-proximally paused Pol II for termination The RNA endonuclease of Integrator subunit 11 is critical for gene attenuation Integrator-repressed genes are enriched in signaling and growth-responsive pathways Copyright Nettet5. des. 2024 · We demonstrate that genes that harbor highly unstable promoter Pol II are those where there is an active process of termination, catalyzed by the Integrator complex. Our data support a model wherein the paused polymerase is inherently stable in the absence of termination factors, consistent with a wealth of biochemical …
Integrator termination complex
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Nettet1. nov. 2024 · The Integrator Complex May Help To Ensure Robust Induction of Genes via Multiple Molecular Mechanisms. (A,B) When cells are under basal conditions, the … Nettet9. sep. 2015 · Integrator is a multi-subunit complex stably associated with the C-terminal domain (CTD) of RNA polymerase II (RNAPII) 1.Integrator is endowed with a core catalytic RNA endonuclease activity, which is required for the 3′-end processing of non-polyadenylated RNAPII-dependent uridylate-rich small nuclear RNA genes (UsnRNAs) …
Nettet25. jan. 2024 · Thus, the Integrator endonuclease INTS11 is implicated in snRNA termination and, possibly more generally, in lncRNA termination. The Restrictor complex may also possess endonuclease activity ... Nettet20. mar. 2024 · The Integrator complex was identified as one of the three cellular machineries performing 3’-end processing of RNAPII transcripts, alongside the …
Nettet20. nov. 2014 · RNA polymerase II (RNAPII) pausing/termination shortly after initiation is a hallmark of gene regulation. Here, we show that negative elongation factor (NELF) interacts with Integrator complex ... Nettet1. sep. 2024 · Instead, H3K4me3 loss leads to reductions in the paused form of Pol II on chromatin while inducing the relative enrichment of the Integrator-PP2A (INTAC) termination complex, leading to reduced ...
NettetThe Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes Highlights • Integrator inhibits transcription elongation at ∼15% of mRNA genes and enhancers • Integrator targets promoter-proximally paused Pol II for termination • The RNA endonuclease of Integrator subunit 11 is critical for gene …
Nettet27. nov. 2024 · We identified a stable Integrator-containing PP2A-AC complex, which we term INTAC. The 3.5-Å-resolution structure shows that nine human Integrator subunits and PP2A core enzyme assemble into a rigid four-module complex. A cruciform-shaped central scaffold is formed by the backbone (INTS1-INTS2-INTS7) and shoulder (INTS5 … cra my business account customer serviceNettet5. des. 2024 · The Integrator Complex Attenuates Expression of Protein-Coding Genes. (A) Cells were treated for 60 h with control double-stranded RNA (dsRNA) or dsRNA … cra my account tfsa roomNettet4. jan. 2024 · Download Citation Integrator is a global promoter-proximal termination complex Integrator is a metazoan-specific protein complex capable of inducing … diy newspaper bowlsNettet5. aug. 2024 · The Integrator complex inhibits transcription elongation at ∼15% of mRNA genes Integrator targets promoter-proximally paused Pol II for termination The RNA … cra my business account for non residentsNettet1. jun. 2024 · The Integrator complex originates in Eukarya and gains additional subunits along with increasing organism/genome complexity. • Integrator is required for 3′-end … diy newspaper headlineNettet8. feb. 2024 · We show that termination of human telomerase RNA transcription is dependent on its promoter, which engages with the multisubunit complex Integrator to interact with RNA polymerase II and... cra my account terms and conditionsNettet5. feb. 2024 · The Integrator complex, which is composed of multiple protein subunits, is involved in global regulation of the process of transcription, during which the … diy newspaper frame